Class Year
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Leor Weinberger |
| Class of 1999 Graduated in 2004 | |
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Undergraduate Institution: University of Maryland, College Park Major: Physics and Biology Origin: Toronto, Canada | |
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Lab: Adam Arkin Location: Calvin lab Website: http://www-chem.ucsd.edu/research/profile.cfm?cid=C21438 |
Research
Cellular biophysics and dynamics of biological networks (immune and biochemical networks)
My thesis research has 2 components: computational and experimental.. Firstly, I have developed a novel mathematical model for the design of gene therapy vectors for HIV-1. I am using this model to engineer HIV-1 gene therapy vectors in the lab and to optimize their performance. These vectors may potentially exploit a novel stochastic pathway to HIV-1 post-integration (proviral) latency. Experimentally testing whether such a stochastic mechanism can lead to HIV-1 proviral latency constitutes the second component of my project.
Publications
- Different Turnover Rate of Hepatitis C Virus Clearance by Different Treatment Regimen using Intereferon-beta, Journal of Hepatology, 2000 v33:313-322.
- Dramatic Rise in Plasma Viremia after CD8+ T-Cell Depletion in SIV-Infected Macaques, Journal of Experimental Medicine, 1999; v189(6):991-8.